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What is Arbutin?

أبريل 26, 2020

Arbutin is a naturally occurring derivative of hydroquinone. It is believed to be one of the best alternatives to hydroquinone as it provides the skin-lightening effect of hydroquinone without some of the risks. Arbutin is now found in a variety of skin care products aimed at lightening skin pigmentation. Skin lightening is often desired for cosmetic purposes to help fade or lighten hyperpigmentation. Hydroquinone is considered the gold standard in skin lightening agents but as effective as it is, it is potent and it should only ever be used under strict medical supervision.

Where does Arbutin come from?

Arbutin, also known as Alpha-Arbutin occurs naturally in several different plant species. Plants with the highest known concentrations are bearberry and mulberry. It is also found in blueberry, cranberry, wheat, and pear varieties. Bearberry has been used for centuries in Europe and North America as a traditional medicine. Before the discovery of modern antibiotics, bearberry was one of the few known naturally-occurring anti-microbial medicines. The antimicrobial activity is due in part to the presence of Arbutin. Bearberry is traditionally used to treat urinary tract infections. Synthetic forms of Arbutin can be created by chemical synthesis or by an enzyme-catalyzed process. In vitro studies of 7% Arbutin appear to have a stronger inhibitory effect on melanin production.

How Does it Work?

Arbutin is composed of hydroquinone with a sugar group attached. The hydroquinone group allows Arbutin to act as an inhibitor of tyrosinase, a key enzyme involved in melanin (pigment) production. This inhibitory activity is due to the structural similarity of the hydroquinone group to tyrosine, which is the natural substrate for tyrosinase. In addition to its innate inhibitory effect, Arbutin may also act as a reservoir that slowly releases hydroquinone. Once absorbed into the skin, enzymes within the body can cleave off the sugar group from Arbutin, releasing hydroquinone. This acts like a built-in safety valve, preventing the skin from being exposed to too much hydroquinone at once.

How Effective is It?

Researchers have been studying Arbutin’s ability to inhibit tyrosinase in skin cells, since the 1990s. There is promising scientific evidence to suggest Arbutin is effective as a skin lightening agent, particularly with regards to the synthetic forms, A-Arbutin and deoxyarbutin. However, most of this evidence is from animal studies or in vitro studies on cultured human skin cells.

What can Arbutin Treat?

  • Hyperpigmentation
  • Lentigines
  • Melasma and Chloasma
  • Freckles

Are there any Side Effects?

It is argued that naturally-sourced Arbutin does not have side effects and safety issues for the user as it is naturally sourced. If the compound is sourced from synthetic sources such as hydroquinone, it is said to be unsafe for topical use on the skin. However, in alkaline conditions, Arbutin converts into hydroquinone, which means that it becomes unsafe in some circumstances. The skin does not have an alkaline environment, that is why Arbutin does not hydrolyze into hydroquinone. So, is Alpha Arbutin safe? Yes, but not hydroquinone.

 

How quickly will I see results while using Arbutin?

Depending the depth of pigmentation visible lightening effects can be seen as early as 4 weeks.

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