Pentravan™: A Revolutionary Transdermal Base

Pentravan™, as introduced by Fagron, is an oil-in-water emulsion base that employs liposome technology to ensure effective and proven transdermal drug penetration. It is a fragrance-free cream that absorbs quickly, leaving a pleasant sensation on the skin.

Key Benefits of Pentravan™:

• Ready for use, eliminating the need to weigh and mix various ingredients.
• Simple 3-step preparation process.
• Compatible with a wide range of Active Pharmaceutical Ingredients (APIs).
• Provides an alternative route of drug administration.
• Allows for individualized therapy and more precise dosing.
• Proven efficacy and reproducibility of transdermal penetration of the API.
• Elegant skin feel, non-greasy, and free from fragrances.

Transdermal Drug Administration Advantages: Transdermal drug administration involves delivering therapeutic amounts of drugs through the skin into the general circulation for systemic effects. This method is effective for treating various conditions and offers several advantages over other administration routes:

• Bypasses gastrointestinal (GI) drug absorption issues caused by gastrointestinal pH, enzymatic activity, and interactions with food, drinks, and other orally administered drugs.
• Serves as an alternative to other administration routes, such as oral or intravenous, especially in cases of vomiting, swallowing difficulties, resistant children, and diarrhea.
• Avoids the first-pass effect, preventing deactivation by digestive and liver enzymes.
• Patient-friendly, non-invasive, and avoids the inconvenience of parenteral therapy.
• Can dissolve a wide range of drugs with different chemical properties, allowing combination therapy with a single transdermal cream.
• Provides prolonged therapy with a single application, enhancing compliance.
• Drug therapy can be quickly discontinued by removing the application.

Pentravan™ stands out as it enhances the ingredients' absorption rate and degree compared to other transdermal bases. This means a higher drug concentration is available in a shorter time to establish the therapy's effect. Additionally, Pentravan™ is a true vanishing cream, leaving no sticky residue and offering a cosmetically elegant skin feel. It is preservative-free and fragrance-free.

Alternative Innovative Products:

• NOURIVAN™ ANTIOX: With antioxidants.
• ESPUMIL®: Foam base.
• FITALITE™: Natural Cremagel.
• EPIFACTOR®: Epidermal Growth.